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Digestive Health Digestive Health

As research continues to emerge from the scientific community, the effects of digestive health on a variety of health outcomes are becoming increasingly apparent.  Our research will help you stand out in the growing area of digestive health research.

Digestive Health
Areas of Expertise
Microbiome

As microbiome research continues to dominate clinical nutrition research and new connections are constantly being made between microbiome composition and long term health markers, INQUIS Clinical Research is well-equipped to design and execute your clinical trial related to the microbiome.  We have experience designing and executing acute studies to detect changes in microbiome composition, as well as long term studies that examine health indicators with shifts in microbiome populations, in addition to experience studying both prebiotics and probiotics and their effects on microbiome populations.

Contact us to learn how we can help you achieve your clinical research objectives.

Publications

Belcheva A, Irrazabal T, Robertson SJ, Streutker C, Maughan H, Rubino S, Moriyama EH, Copeland JK, Surendra A, Kumar S, Green B, Geddes K, Pezo RC, Navarre WW, Milosevic M, Wilson BC, Girardin SE, Wolever TMS, Edelmann W, Guttman DS, Philpott DJ, Martin A. Gut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells. Cell 2014;158(2):288-299. doi: 10.1016/j.cell.2014.04.051.

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Rahat-Rozenbloom S, Fernandes J, Cheng J, Wolever TMS. Acute increases in serum colonic short-chain fatty acids elicited by inulin do not increase GLP-1 or PYY responses but may reduce ghrelin in lean and overweight humans. Eur J Clin Nutr 2017;71(8):953-958. doi: 10.1038/ejcn.2016.249.

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Fernandes J, Su W, Rahat-Rozenbloom S, Wolever TM, Comelli EM. Adiposity, gut microbiota and faecal short chain fatty acids are linked in adult humans. Nutr Diabetes 2014;4:e121. doi: 10.1038/nutd.2014.23.

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Layden BT, Yalamanchi SK, Wolever TMS, Dunaif A, Lowe WL JR. Negative association of acetate with visceral adipose tissue and insulin levels. Diabetes Metab Syndr Obes 2012;5:49-55. doi: 10.2147/DMSO.S29244.

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Tarini J, Wolever TMS. The fermentable fibre inulin increases postprandial serum short-chain fatty acids and reduces free-fatty acids and ghrelin in healthy subjects. Appl Physiol Nutr Metab 2010;35(1):9-16. doi: 10.1139/H09-119.

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Constipation/Laxation

At  INQUIS Clinical Research, we have experience designing and executing constipation/laxation trials to be used as support for health claims and novel fiber claims. With an extensive participant database, we can recruit the appropriate study population for your research objectives.

Contact us to learn how we can help you achieve your clinical research objectives.

Publications

Tarini J, Wolever TMS. The fermentable fibre inulin increases postprandial serum short-chain fatty acids and reduces free-fatty acids and ghrelin in healthy subjects. Appl Physiol Nutr Metab 2010;35(1):9-16. doi: 10.1139/H09-119.

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Wolever TM, Vuksan V, Eshuis H, Spadafora P, Peterson RD, Chao ES, Storey ML, Jenkins DJ. Effect of method of administration of psyllium on glycemic response and carbohydrate digestibility. J Am Coll Nutr 1991;10(4):364-71.

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Gastrointestinal Tolerance & Digestibility

Determining whether a food or ingredient is digested can be established by appearance of glucose in the blood and the stimulation of insulin response. Our team of researchers is experienced in determining digestibility, as well as bioavailability and bioequivalency.

At INQUIS Clinical Research, our team of researchers can develop and execute both acute and long term research study designs to determine the gastrointestinal tolerance of foods and ingredients, sweeteners and fibers.

Contact us to learn how we can help you achieve your clinical research objectives.

Publications

Wolever TMS, Chiasson J-L, Josse RG, Leiter LA, Maheux P, Rabasa-Lhoret R, Rodger NW, Ryan EA. Effects of changing the amount and source of dietary carbohydrates on symptoms and dietary satisfaction over a 1-year period in subjects with type 2 diabetes: Canadian trial of carbohydrates in diabetes (CCD). Can J Diab 2017;41:164-76.

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Wolever TMS, van Klinken BJW, Bordenave N, Kaczmarczyk M, Jenkins AL, Chu YF, Harkness L. Reformulating cereal bars: high resistant starch reduces in vitro digestibility but not in vivo glucose or insulin response; whey protein reduces glucose but disproportionately increases insulin. Am J Clin Nutr 2016;104:(4)

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Rahat-Rozenbloom S, Fernandes J, Cheng J, Wolever TMS. Acute increases in serum colonic short-chain fatty acids elicited by inulin do not increase GLP-1 or PYY responses but may reduce ghrelin in lean and overweight humans. Eur J Clin Nutr 2017;71(8):953-958. doi: 10.1038/ejcn.2016.249.

Read More

Belcheva A, Irrazabal T, Robertson SJ, Streutker C, Maughan H, Rubino S, Moriyama EH, Copeland JK, Surendra A, Kumar S, Green B, Geddes K, Pezo RC, Navarre WW, Milosevic M, Wilson BC, Girardin SE, Wolever TMS, Edelmann W, Guttman DS, Philpott DJ, Martin A. Gut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells. Cell 2014;158(2):288-299. doi: 10.1016/j.cell.2014.04.051.

Read More

Wolever TMS, Chiasson J-L, Josse RG, Hunt JA, Palmason C, Rodger NW, Ross SA, Ryan EA, Tan MH. No relationship between carbohydrate intake and effect of acarbose on HbA1c or gastrointestinal symptoms in type 2 diabetic subjects consuming 30-60% of energy from carbohydrate. Diabetes Care 1998;21:1612-18.

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Services

INQUIS Clinical Research offers a complete suite of services to help you structure your trial from end to end. We ensure you receive a custom-designed program that covers every aspect of your research needs seamlessly from beginning to end. We can partner as intensively as needed for clients who require our expertise with only some aspects of their clinical trial.

Features of our clinical trial services include:

Expertise
Expertise
Protocol Development
Expertise
Expertise
Ethics Submission
Expertise
Expertise
Recruitment
Expertise
Expertise
Trial Execution
Expertise
Expertise
Clinical Trial Management
Expertise
Expertise
Biological Sample Analysis
Expertise
Expertise
Biostatistics Calculation
Expertise
Expertise
Publication
Expertise
Expertise
SR&ED Preparation
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