Weight Loss & Satiety – Inquis Clinical Research

Weight Loss & Satiety

As obesity rates continue to rise, weight loss and satiety remain high priority to consumers. With extensive experience in weight loss trials, food intake trials, and measures of satiety and satiation, INQUIS Clinical Research works with our clients to design and conduct trials unique to their study products and objectives.

Areas of Expertise

Appetite and food intake studies are increasingly sought-after, as consumers continue to demand products that promote feelings of fullness. At INQUIS Clinical Research, we conduct trials that investigate both subjective measures of satiety, including visual analogue scales and feelings of hunger measurement, as well as objective measures of satiety, such as unrestricted food intake studies. With access to groups of both restrained and unrestrained eaters, as well as the ability to conduct studies that look at both satiation and satiety, we are able to design and execute the research trial that meets your needs.

Contact us to learn how we can help you achieve your clinical research objectives.

Publications

Wolever, T. M., Campbell, J. E., Au-Yeung, F., Dioum, E. H. M., Shete, V., & Chu, Y. Chia seeds (Salvia hispanica L.), incorporated into cookies, reduce postprandial glycaemic variability but have little or no effect on subjective appetite. Journal of Functional Foods, 109, 105806. Published October 2023. https://doi.org/10.1016/j.jff.2023.105806

Wolever TMS, Tosh SM, Spruill SE, et al. Increasing oat β-glucan viscosity in a breakfast meal slows gastric emptying and reduces glycemic and insulinemic responses but has no effect on appetite, food intake, or plasma ghrelin and PYY responses in healthy humans: a randomized, placebo-controlled, crossover trial. Am J Clin Nutr. 2020;111(2):319-328. doi:10.1093/ajcn/nqz285

Kendall CW, West SG, Augustin LS, Esfahani A, Vidgen E, Bashyam B, Sauder KA, Campbell J, Chiavaroli L, Jenkins AL, Jenkins DJ. Acute effects of pistachio consumption on glucose and insulin, satiety hormones and endothelial function in the metabolic syndrome. Eur J Clin Nutr 2014;68(3):370-5. doi: 10.1038/ejcn.2013.275.

Vuksan V, Jenkins AL, Dias AG, Lee AS, Jovanovski E, Rogovik AL, Hanna A. Reduction in postprandial glucose excursion and prolongation of satiety: possible explanation of the long-term effects of whole grain Salba. Eur J Clin Nutr 2010;64(4):436-8. doi: 10.1038/ejcn.2009.159.

Freeland KR, Anderson GH, Wolever TMS. Acute effects of dietary fibre and glycaemic carbohydrate on appetite and food intake in healthy males. Appetite 2009;52:58-64. doi: 10.1016/j.appet.2008.08.001

Vuksan V, Panahi S, Lyon M, Rogovik AL, Jenkins AL, Leiter LA, Viscosity of fiber preloads affects food intake in adolescents. NutrMetab Cardiovasc Dis 2009;19:498-503. doi: 10.1016/j.numecd.2008.09.006

Abou-Samra R, Wolever TMS, Anderson GH. Enhanced food intake regulatory responses after a glucose drink in hyperinsulinemic men. Int J Obesity 2007;31:1222-31. doi: 10.1038/sj.ijo.0803565.

Anderson GH, Catherine NLA, Woodend DM, Wolever TMS. Inverse association between the effect of carbohydrates on blood glucose and subsequent short-term food intake in young men. Am J Clin Nutr 2002;76:1023-30. doi: 10.1093/ajcn/76.5.1023

Stewart SL, Black RM, Wolever TMS, Anderson GH. The relationship between glycaemic response to breakfast cereals and subjective appetite and food intake. Nutr Res 1997;17:1249-60.

Wolever TMS, Jenkins DJA, Josse RG, Wong GS, Lee R, Anderson GH. Relationship between fasting serum tryptophan/large neutral amino acid ratio and reported hunger in subjects with diabetes. Diabetes Res 1988;9:131-37.

As obesity rates continue to soar, weight loss and weight maintenance continue to be priorities to consumers as well as food manufacturers. We have experience recruiting motivated and reliable participants for weight loss trials and managing the challenges of these longer-term studies. With the options of intervention periods followed by a follow-up maintenance phase, we can design a weight loss trial unique to your research needs.
We also examine changes in gut hormones and changes in body composition to better characterize the mechanism of action of your product.

Contact us to learn how we can help you achieve your clinical research objectives.

Publications

Vuksan V, Jenkins AL, Brissette C, Choleva L, Jovanovski E, Gibbs AL, Bazinet RP, Au-Yeung F, Zurbau A, Ho HV, Duvnjak L, Sievenpiper JL, Josse RG, Hanna A. Salba-chia (Salvia hispanica L.) in the treatment of overweight and obese patients with type 2 diabetes: A double-blind randomized controlled trial. Nutr Metab Cardiovasc Dis 2017;27(2):138-146. doi: 10.1016/j.numecd.2016.11.124.

Wolever TM, Chiasson JL, Josse RG, Hunt JA, Palmason C, Rodger NW, Ross SA, Ryan EA, Tan MH. Small weight loss on long-term acarbose therapy with no change in dietary pattern or nutrient intake of individuals with non-insulin-dependent diabetes. Int J Obes Relat Metab Disord 1997;21(9):756-763. doi:10.1038/sj.ijo.0800468.

Sievenpiper JL, de Souza RJ, Mirrahimi A, Yu ME, Carleton AJ, Beyene J, Chiavaroli L, Di Buono M, Jenkins AL, Leiter LA, Wolever TMS, Kendall CW, Jenkins DJ. Effect of fructose on body weight in controlled feeding trials: a systematic review and meta-analysis. Ann Intern Med 2012;156(4):291-304. doi: 10.7326/0003-4819-156-4-201202210-00007.

Jovanovski E, Mazhar N, Komishon A, Khayyat R, Li D, Blanco Mejia S, Khan T, Jenkins AL, Smircic-Duvnjak L, Sievenpiper JL, Vuksan V. Effect of viscous fiber supplementation on obesity indicators in individuals consuming calorie-restricted diets: a systematic review and meta-analysis of randomized controlled trials. Eur J Nutr. 2020 Mar 20. doi: 10.1007/s00394-020-02224-1.

Tracking changes in body composition over time with a specific treatment helps to better understand the mechanism of action as well as potential long-term effects. At INQUIS Clinical Research, our research includes DEXA (dual energy x-ray absorptiometry) scans to determine changes in fat composition over time, as well as BIA (bioelectrical impedance analysis) to monitor changes body fat percentages over time.

Contact us to learn how we can help you achieve your clinical research objectives.

Publications

Fernandes J, Su W, Rahat-Rozenbloom S, Wolever TM, Comelli EM. Adiposity, gut microbiota and faecal short chain fatty acids are linked in adult humans. Nutr Diabetes 2014;4:e121. doi: 10.1038/nutd.2014.23.

Layden BT, Yalamanchi SK, Wolever TMS, Dunaif A, Lowe WL JR. Negative association of acetate with visceral adipose tissue and insulin levels. Diabetes Metab Syndr Obes 2012;5:49-55. doi: 10.2147/DMSO.S29244.

Kochan AM, Wolever TM, Chetty VT, Anand SS, Gerstein HC, Sharma AM. Glycemic index predicts individual glucose responses after self-selected breakfasts in free-living, abdominally obese adults. J Nutr 2012 Jan;142(1):27-32. doi: 10.3945/jn.111.146571.

Gut hormones are important indicators of satiety and may reveal the mechanism of action of your product. At INQUIS Clinical Research, we measure GLP-1, GIP, PYY, ghrelin, and adiponectin in order to achieve our clients’ research objectives when determining the effect of their products on feelings of fullness.

Contact us to learn how we can help you achieve your clinical research objectives.

Publications

Rahat-Rozenbloom S, Fernandes J, Cheng J, Wolever TMS. Acute increases in serum colonic short-chain fatty acids elicited by inulin do not increase GLP-1 or PYY responses but may reduce ghrelin in lean and overweight humans. Eur J Clin Nutr. 2016;71(8):953-958. doi: 10.1038/ejcn.2016.249.

Tarini J, Wolever T. The fermentable fibre inulin increases postprandial serum short-chain fatty acids and reduces free-fatty acids and ghrelin in healthy subjects. Appl Physiol Nutr Metab 2010;35(1):9-16. doi:10.1139/h09-119

Services

INQUIS Clinical Research offers a complete suite of services to help you structure your trial from end to end. We ensure you receive a custom-designed program that covers every aspect of your research needs seamlessly from beginning to end. We can partner as intensively as needed for clients who require our expertise with only some aspects of their clinical trial.

Features of our clinical trial services include:

Protocol Development

Ethics Submission

Recruitment

Trial Execution

Clinical Trial Management

Biological Sample Analysis

Biostatistics Calculation

Publication

SR&ED Preparation

How can we help you achieve your research objectives?